2228955-02-8
2228955-02-8 structure
- Name: SOS1 activator 17
- Chemical Name: SOS1 activator 17
- CAS Number: 2228955-02-8
- Molecular Formula: C26H27Cl2N5O
- Molecular Weight: 496.436
- Create Date: 2020-01-15 06:46:29
- Modify Date: 2024-01-06 18:31:42
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SOS1 activator 17 is a small molecule activator of guanine nucleotide exchange factor SOS1 with EC50 of 0.8 uM, modulates RAS signaling in vitro; activates the nucleotide exchange process at submicromolar concentrations in vitro, increases levels of active RAS-GTP in HeLa cells, and elicits signaling changes in the MAPK-ERK pathway, resulting in a decrease in pERK1/2T202/Y204 protein levels.
| Name | SOS1 activator 17 |
|---|
| Description | SOS1 activator 17 is a small molecule activator of guanine nucleotide exchange factor SOS1 with EC50 of 0.8 uM, modulates RAS signaling in vitro; activates the nucleotide exchange process at submicromolar concentrations in vitro, increases levels of active RAS-GTP in HeLa cells, and elicits signaling changes in the MAPK-ERK pathway, resulting in a decrease in pERK1/2T202/Y204 protein levels. |
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| References | References 1. Abbott JR, et al. J Med Chem. 2018 Jul 11. doi: 10.1021/acs.jmedchem.8b00360. View Related Products by Target Ras |
| Molecular Formula | C26H27Cl2N5O |
|---|---|
| Molecular Weight | 496.436 |