2245237-53-8

2245237-53-8 structure
2245237-53-8 structure
  • Name: SOS1 activator 1
  • Chemical Name: SOS1 activator 1
  • CAS Number: 2245237-53-8
  • Molecular Formula: C26H32ClFN6
  • Molecular Weight: 483.02
  • Catalog: Signaling Pathways GPCR/G Protein Ras
  • Create Date: 2022-05-24 17:15:26
  • Modify Date: 2025-08-25 16:28:06
  • SOS1 activator 1 (Compound 64) is a potent activator of SOS1-mediated nucleotide exchange with a Kd of 44 nM. SOS1 is a guanine nucleotide exchange factor that catalyzes the exchange of GDP for GTP on RAS[1].

Name SOS1 activator 1
Description SOS1 activator 1 (Compound 64) is a potent activator of SOS1-mediated nucleotide exchange with a Kd of 44 nM. SOS1 is a guanine nucleotide exchange factor that catalyzes the exchange of GDP for GTP on RAS[1].
Related Catalog
References

[1]. Timothy R Hodges, et al. Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS. J Med Chem. 2018 Oct 11;61(19):8875-8894.

Molecular Formula C26H32ClFN6
Molecular Weight 483.02
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