2216763-38-9
2216763-38-9 structure
- Name: Rheb inhibitor NR1
- Chemical Name: Rheb inhibitor NR1
- CAS Number: 2216763-38-9
- Molecular Formula: C25H19BrCl2N2O3S
- Molecular Weight: 578.302
- Catalog: Signaling Pathways PI3K/Akt/mTOR mTOR
- Create Date: 2020-01-20 11:45:56
- Modify Date: 2024-01-06 18:37:36
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Rheb inhibitor NR1 is a small molecule that binds Rheb in the switch II domain (IC50=2.1 uM, Kd=1.5 uM) and selectively blocks mTORC1 signaling, potently inhibits mTORC1 driven phosphorylation of S6K1 but does not inhibit phosphorylation of AKT or ERK; in contrast to rapamycin, NR1 does not cause inhibition of mTORC2 upon prolonged treatment, potently and selectively inhibits mTORC1 in mouse kidney and muscle in vivo.
| Name | Rheb inhibitor NR1 |
|---|
| Description | Rheb inhibitor NR1 is a small molecule that binds Rheb in the switch II domain (IC50=2.1 uM, Kd=1.5 uM) and selectively blocks mTORC1 signaling, potently inhibits mTORC1 driven phosphorylation of S6K1 but does not inhibit phosphorylation of AKT or ERK; in contrast to rapamycin, NR1 does not cause inhibition of mTORC2 upon prolonged treatment, potently and selectively inhibits mTORC1 in mouse kidney and muscle in vivo. |
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| References | References 1. Mahoney SJ, et al. Nat Commun. 2018 Feb 7;9(1):548. View Related Products by Target Small GTPase |
| Molecular Formula | C25H19BrCl2N2O3S |
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| Molecular Weight | 578.302 |
| Hazard Codes | Xi |
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