2058116-54-2
2058116-54-2 structure
- Name: MDVN-1003
- Chemical Name: MDVN-1003
- CAS Number: 2058116-54-2
- Molecular Formula: C22H20FN7O
- Molecular Weight: 417.45
- Create Date: 2020-01-12 05:55:50
- Modify Date: 2025-08-25 11:48:04
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A first-in-class, selective, orally bioavailable, dual inhibitor of BTK and PI3Kδ kinases with IC50 of 32.3 nM and 16.9 nM, respectively; inhibits B cell activation upon BCR cross-linking ex vivo and in vivo, induces apoptosis and decreases viability of DOHH-2 cells; shows significant anti-tumor effects in an NHL xenograft model in mice.
| Name | MDVN-1003 |
|---|
| Description | A first-in-class, selective, orally bioavailable, dual inhibitor of BTK and PI3Kδ kinases with IC50 of 32.3 nM and 16.9 nM, respectively; inhibits B cell activation upon BCR cross-linking ex vivo and in vivo, induces apoptosis and decreases viability of DOHH-2 cells; shows significant anti-tumor effects in an NHL xenograft model in mice. |
|---|---|
| References | References 1. Alfaro J, et al. J Pharmacol Exp Ther. 2017 May;361(2):312-321. View Related Products by Target BTK |
| Molecular Formula | C22H20FN7O |
|---|---|
| Molecular Weight | 417.45 |