1959588-75-0
1959588-75-0 structure
- Name: Chiglitazar
- Chemical Name: Chiglitazar
- CAS Number: 1959588-75-0
- Molecular Formula: C36H28FN2NaO4
- Molecular Weight: 594.618
- Create Date: 2020-01-12 11:10:51
- Modify Date: 2024-09-17 12:48:34
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Chiglitazar (CS-038, CS038) is a potent, dual PPARα/γ dual agonist with EC50 of 1.2, 0.08, 1.7 uM for PPARα, PPARγ and PPARδ, respectively; inhibited alanine gluconeogenesis, lowered the hepatic glycogen level in MSG obese rats. Like rosiglitazone, chiglitazar promoted the differentiation of adipocytes and decreased the maximal diameter of adipocytes; Chiglitazar reduced plasma triglyceride, total cholesterol (TCHO), nonesterified fatty acids (NEFA) and low density lipoprotein-cholesterol levels; lowered hepatic triglyceride and TCHO contents; decreased muscular NEFA level. Unlike rosiglitazone, chiglitazar showed significant increase of mRNA expression of PPARα, CPT1, BIFEZ, ACO and CYP4A10 in the liver of MSG obese rats. Diabetes Phase 3 Clinical
| Name | Chiglitazar |
|---|
| Description | Chiglitazar (CS-038, CS038) is a potent, dual PPARα/γ dual agonist with EC50 of 1.2, 0.08, 1.7 uM for PPARα, PPARγ and PPARδ, respectively; inhibited alanine gluconeogenesis, lowered the hepatic glycogen level in MSG obese rats. Like rosiglitazone, chiglitazar promoted the differentiation of adipocytes and decreased the maximal diameter of adipocytes; Chiglitazar reduced plasma triglyceride, total cholesterol (TCHO), nonesterified fatty acids (NEFA) and low density lipoprotein-cholesterol levels; lowered hepatic triglyceride and TCHO contents; decreased muscular NEFA level. Unlike rosiglitazone, chiglitazar showed significant increase of mRNA expression of PPARα, CPT1, BIFEZ, ACO and CYP4A10 in the liver of MSG obese rats. Diabetes Phase 3 Clinical |
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| References | References 1. Li PP, et al. Br J Pharmacol. 2006 Jul;148(5):610-8. 2. He BK, et al. PPAR Res. 2012;2012:546548. 3. Pan DS, et al. PPAR Res. 2017;2017:4313561. View Related Products by Target PPAR Diabetes |
| Molecular Formula | C36H28FN2NaO4 |
|---|---|
| Molecular Weight | 594.618 |