1881276-00-1
1881276-00-1 structure
- Name: AI-10-104
- Chemical Name: AI-10-104
- CAS Number: 1881276-00-1
- Molecular Formula: C14H10F3N3O2
- Molecular Weight: 309.248
- Create Date: 2020-01-12 10:51:49
- Modify Date: 2024-01-19 18:53:07
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AI-10-104 is a small molecule inhibitor that interferes with CBFβ binding to RUNX proteins with IC50 of 1.25 uM in FRET assays; reduces RUNX transcriptional activity by interfering with the formation of the CBFβ/RUNX1 and/or CBFβ/RUNX3 heterodimers in T-ALL cells; impairs the growth of human T-ALL cell lines and primary patient samples (GI50=2.4 uM).
| Name | AI-10-104 |
|---|
| Description | AI-10-104 is a small molecule inhibitor that interferes with CBFβ binding to RUNX proteins with IC50 of 1.25 uM in FRET assays; reduces RUNX transcriptional activity by interfering with the formation of the CBFβ/RUNX1 and/or CBFβ/RUNX3 heterodimers in T-ALL cells; impairs the growth of human T-ALL cell lines and primary patient samples (GI50=2.4 uM). |
|---|---|
| References | References 1. Choi A, et al. Blood. 2017 Oct 12;130(15):1722-1733. 2. Illendula A, et al. EBioMedicine. 2016 Jun;8:117-31. View Related Products by Target RUNX1-CBFβ |
| Molecular Formula | C14H10F3N3O2 |
|---|---|
| Molecular Weight | 309.248 |