882288-28-0

882288-28-0 structure

Name: AI-3
Chemical Name: Benzo[c]thiophen-4(5H)-one, 1-chloro-6,7-dihydro-6,6-dimethyl-3-(methylsulfonyl)
CAS Number: 882288-28-0
Molecular Formula: C₁₁H₁₃ClO₃S₂
Molecular Weight: 292.80200
Catalog: Research Areas Cancer
Create Date: 2016-05-05 04:38:41
Modify Date: 2025-09-04 17:26:07
AI-3 is a potent ARE (antioxidant response element) activator. AI-3 increases the NQO1 at the transcript levels and protein expression levels. AI-3 has the potential for the research of oxidative stress related diseases[1].

Name	Benzo[c]thiophen-4(5H)-one, 1-chloro-6,7-dihydro-6,6-dimethyl-3-(methylsulfonyl)
Synonyms	L-368,899 hydrochloride

Description	AI-3 is a potent ARE (antioxidant response element) activator. AI-3 increases the NQO1 at the transcript levels and protein expression levels. AI-3 has the potential for the research of oxidative stress related diseases[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
Target	ARE[1]
In Vitro	AI-3 (0.1, 0.3, 1, 3.2, 10, 32 µM; 12, 24 h) 在 IMR-32 细胞中以剂量依赖方式增加 NQO1 的转录水平和蛋白质表达水平[1] . AI-3 (10 µM; 2-24 h) 诱导 GSH 合成从 4 小时开始到 24 小时[1]。 AI-3 在 IMR-32 细胞中的生物活性需要 Nrf2 和 PI3K的参与[1]。 Western Blot Analysis[1] Cell Line: IMR-32 cells Concentration: 0.1, 0.3, 1, 3.2, 10, 32 µM Incubation Time: 24 h Result: Induced NQO1 protein expression starting from 0.3 μM.
References	[1]. Wang R, et al. In vitro and in vivo characterization of a tunable dual-reactivity probe of the Nrf2-ARE pathway. ACS Chem Biol. 2013 Aug 16;8(8):1764-74.