1874254-18-8
1874254-18-8 structure
- Name: PCSK9 modulator 10
- Chemical Name: PCSK9 modulator 10
- CAS Number: 1874254-18-8
- Molecular Formula: C15H6ClF6NO
- Molecular Weight: 365.659
- Create Date: 2020-01-20 14:42:56
- Modify Date: 2024-09-08 12:21:01
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PCSK9 modulator 10 is a highly potent, orally active PCSK9 modulator that inhibits PCSK9 production in HepG2 cells with IC50 of 0.036 nM; significantly reduces LDL-c levels by 46% and 57% at 0.01 and 0.04 mg/kg in vivo without deaths or abnormal general signs.
| Name | PCSK9 modulator 10 |
|---|
| Description | PCSK9 modulator 10 is a highly potent, orally active PCSK9 modulator that inhibits PCSK9 production in HepG2 cells with IC50 of 0.036 nM; significantly reduces LDL-c levels by 46% and 57% at 0.01 and 0.04 mg/kg in vivo without deaths or abnormal general signs. |
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| References | References 1. Daniel Pettersen, et al. Small molecule modulators of PCSK9-a literature and patent overview. Bioorg Med Chem Lett. 2018 Feb 26. pii: S0960-894X(18)30151-3. View Related Products by Target PCSK9 |
| Molecular Formula | C15H6ClF6NO |
|---|---|
| Molecular Weight | 365.659 |