1853176-89-2
1853176-89-2 structure
- Name: DS86760016
- Chemical Name: DS86760016
- CAS Number: 1853176-89-2
- Molecular Formula: C9H11BClNO4
- Molecular Weight: 243.45
- Catalog: Signaling Pathways Anti-infection Bacterial
- Create Date: 2020-01-20 12:44:56
- Modify Date: 2024-01-10 07:39:53
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DS86760016 is a novel selective bacterial leucyl-tRNA synthetase (LeuRS) inhibitor with IC50 of 0.38 uM (Escherichia coli, LeuRS); inhibits Pseudomonas aeruginosa and Acinetobacter baumannii with IC50 of 0.62 and 0.16 uM, respectively; shows active against MDR Gram-negative bacteria (MIC 0.25-2 ug/mL) with an improved pharmacokinetic profile compared with GSK2251052; also shows lower mutant prevention concentrations against P. aeruginosa compared to GSK2251052.
| Name | DS86760016 |
|---|
| Description | DS86760016 is a novel selective bacterial leucyl-tRNA synthetase (LeuRS) inhibitor with IC50 of 0.38 uM (Escherichia coli, LeuRS); inhibits Pseudomonas aeruginosa and Acinetobacter baumannii with IC50 of 0.62 and 0.16 uM, respectively; shows active against MDR Gram-negative bacteria (MIC 0.25-2 ug/mL) with an improved pharmacokinetic profile compared with GSK2251052; also shows lower mutant prevention concentrations against P. aeruginosa compared to GSK2251052. |
|---|---|
| References | References 1. Purnapatre KP, et al. Antimicrob Agents Chemother. 2018 Feb 5. pii: AAC.01987-17. View Related Products by Target Bacterial |
| Molecular Formula | C9H11BClNO4 |
|---|---|
| Molecular Weight | 243.45 |