DS86760016
Modify Date: 2025-08-25 11:44:14
DS86760016 structure
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Common Name | DS86760016 | ||
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| CAS Number | 1853176-89-2 | Molecular Weight | 243.45 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C9H11BClNO4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of DS86760016DS86760016 is a novel selective bacterial leucyl-tRNA synthetase (LeuRS) inhibitor with IC50 of 0.38 uM (Escherichia coli, LeuRS); inhibits Pseudomonas aeruginosa and Acinetobacter baumannii with IC50 of 0.62 and 0.16 uM, respectively; shows active against MDR Gram-negative bacteria (MIC 0.25-2 ug/mL) with an improved pharmacokinetic profile compared with GSK2251052; also shows lower mutant prevention concentrations against P. aeruginosa compared to GSK2251052. |
| Name | DS86760016 |
|---|
| Description | DS86760016 is a novel selective bacterial leucyl-tRNA synthetase (LeuRS) inhibitor with IC50 of 0.38 uM (Escherichia coli, LeuRS); inhibits Pseudomonas aeruginosa and Acinetobacter baumannii with IC50 of 0.62 and 0.16 uM, respectively; shows active against MDR Gram-negative bacteria (MIC 0.25-2 ug/mL) with an improved pharmacokinetic profile compared with GSK2251052; also shows lower mutant prevention concentrations against P. aeruginosa compared to GSK2251052. |
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| References | References 1. Purnapatre KP, et al. Antimicrob Agents Chemother. 2018 Feb 5. pii: AAC.01987-17. View Related Products by Target Bacterial |
| Molecular Formula | C9H11BClNO4 |
|---|---|
| Molecular Weight | 243.45 |