1801163-44-9
1801163-44-9 structure
- Name: ZINC 39395747
- Chemical Name: ZINC 39395747
- CAS Number: 1801163-44-9
- Molecular Formula: C12H11N3O2S2
- Molecular Weight: 293.359
- Create Date: 2020-01-11 17:43:49
- Modify Date: 2025-08-25 13:07:29
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A novel potent derivative of propylthiouracil that functions as a cell-active inhibitor of cytochrome b5 reductase 3 (CYB5R3) with IC50 of 9.14 uM; significantly increases NO bioavailability in renal vascular cells, augments renal blood flow, and decreases systemic blood pressure in response to vasoconstrictors in spontaneously hypertensive rats.
| Name | ZINC 39395747 |
|---|
| Description | A novel potent derivative of propylthiouracil that functions as a cell-active inhibitor of cytochrome b5 reductase 3 (CYB5R3) with IC50 of 9.14 uM; significantly increases NO bioavailability in renal vascular cells, augments renal blood flow, and decreases systemic blood pressure in response to vasoconstrictors in spontaneously hypertensive rats. |
|---|---|
| References | References 1. Rahaman MM, et al. J Biol Chem. 2015 Jul 3;290(27):16861-72. View Related Products by Target Other Targets |
| Molecular Formula | C12H11N3O2S2 |
|---|---|
| Molecular Weight | 293.359 |