1581764-31-9
1581764-31-9 structure
- Name: EBI-907
- Chemical Name: EBI-907
- CAS Number: 1581764-31-9
- Molecular Formula: C23H21ClF2N4O3S
- Molecular Weight: 506.95
- Create Date: 2020-01-12 11:29:49
- Modify Date: 2024-04-11 11:22:43
-
EBI-907 is a highly potent, selective, orally active B-Raf V600E inhibitor with enzyme IC50 of 7 nM, A375 cell growth IC50 of 13 nM; shows no anti-proliferative effects on the growth of Calu-6 cells carrying a wild-type B-Raf, exhibiting at least 40-fold (455 nM) selectivity towards B-RafV600E-dependent cells lines; demonstrates excellent in vivo efficacy in B-Raf(V600E) dependent Colo-205 tumor xenograft models in mouse.
| Name | EBI-907 |
|---|
| Description | EBI-907 is a highly potent, selective, orally active B-Raf V600E inhibitor with enzyme IC50 of 7 nM, A375 cell growth IC50 of 13 nM; shows no anti-proliferative effects on the growth of Calu-6 cells carrying a wild-type B-Raf, exhibiting at least 40-fold (455 nM) selectivity towards B-RafV600E-dependent cells lines; demonstrates excellent in vivo efficacy in B-Raf(V600E) dependent Colo-205 tumor xenograft models in mouse. |
|---|---|
| References | References 1. Lu B, et al. Bioorg Med Chem Lett. 2016 Feb 1;26(3):819-23. View Related Products by Target Raf |
| Molecular Formula | C23H21ClF2N4O3S |
|---|---|
| Molecular Weight | 506.95 |