EBI-907

Modify Date: 2025-10-06 23:04:51

EBI-907 Structure
EBI-907 structure
 Common Name EBI-907
CAS Number 1581764-31-9 Molecular Weight 506.95
Density N/A Boiling Point N/A
Molecular Formula C23H21ClF2N4O3S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of EBI-907


EBI-907 is a highly potent, selective, orally active B-Raf V600E inhibitor with enzyme IC50 of 7 nM, A375 cell growth IC50 of 13 nM; shows no anti-proliferative effects on the growth of Calu-6 cells carrying a wild-type B-Raf, exhibiting at least 40-fold (455 nM) selectivity towards B-RafV600E-dependent cells lines; demonstrates excellent in vivo efficacy in B-Raf(V600E) dependent Colo-205 tumor xenograft models in mouse.

 Names

Name EBI-907

 EBI-907 Biological Activity

Description EBI-907 is a highly potent, selective, orally active B-Raf V600E inhibitor with enzyme IC50 of 7 nM, A375 cell growth IC50 of 13 nM; shows no anti-proliferative effects on the growth of Calu-6 cells carrying a wild-type B-Raf, exhibiting at least 40-fold (455 nM) selectivity towards B-RafV600E-dependent cells lines; demonstrates excellent in vivo efficacy in B-Raf(V600E) dependent Colo-205 tumor xenograft models in mouse.
References References 1. Lu B, et al. Bioorg Med Chem Lett. 2016 Feb 1;26(3):819-23. View Related Products by Target Raf

 Chemical & Physical Properties

Molecular Formula C23H21ClF2N4O3S
Molecular Weight 506.95
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Chemsrc provides EBI-907(CAS#:1581764-31-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of EBI-907 are included as well.>> amp version: EBI-907

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