1446352-67-5
1446352-67-5 structure
- Name: PK-7088
- Chemical Name: PK-7088
- CAS Number: 1446352-67-5
- Molecular Formula: C14H13N3
- Molecular Weight: 223.279
- Catalog: Research Areas Cancer
- Create Date: 2020-01-20 17:12:56
- Modify Date: 2024-05-01 20:04:29
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PK-7088 is a small molecule mutant p53 Y220C reactivator, promotes correct folding of Y220 mutant p53 and induces expression of p53 targets p21 and the Noxa, triggers nuclear export of the pro-apoptotic Bax protein to mitochondria.
| Name | PK-7088 |
|---|
| Description | PK-7088 is a small molecule mutant p53 Y220C reactivator, promotes correct folding of Y220 mutant p53 and induces expression of p53 targets p21 and the Noxa, triggers nuclear export of the pro-apoptotic Bax protein to mitochondria. |
|---|---|
| References | References 1. Liu X, et al. Nucleic Acids Res. 2013 Jul;41(12):6034-44. 2. Joerger AC, et al. Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15056-61. 3. Bykov VJ, et al. FEBS Lett. 2014 Aug 19;588(16):2622-7. View Related Products by Target MDM2-p53 |
| Molecular Formula | C14H13N3 |
|---|---|
| Molecular Weight | 223.279 |