1428640-39-4
1428640-39-4 structure
- Name: HXJ 42
- Chemical Name: HXJ 42
- CAS Number: 1428640-39-4
- Molecular Formula: C15H15Cl2N5O
- Molecular Weight: 352.219
- Create Date: 2020-01-12 08:38:50
- Modify Date: 2025-08-25 17:46:56
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A PP1 analog that has greater selectivity and potency for Zap-70(AS) over wild-type Zap-70, as assessed by Erk and Lat phosphorylation, as well as by proliferative responses of mature CD4+ cells; effectively rescues Zap70(AS) OT-I cells from negative selection.
| Name | HXJ 42 |
|---|
| Description | A PP1 analog that has greater selectivity and potency for Zap-70(AS) over wild-type Zap-70, as assessed by Erk and Lat phosphorylation, as well as by proliferative responses of mature CD4+ cells; effectively rescues Zap70(AS) OT-I cells from negative selection. |
|---|---|
| References | References 1. Au-Yeung BB, et al. Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):E3679-88. 2. Au-Yeung BB, et al. Nat Immunol. 2014 Jul;15(7):687-94. View Related Products by Target T Cell Receptor (TCR) |
| Molecular Formula | C15H15Cl2N5O |
|---|---|
| Molecular Weight | 352.219 |