1366231-70-0
1366231-70-0 structure
- Name: DB2115
- Chemical Name: DB2115
- CAS Number: 1366231-70-0
- Molecular Formula: C32H30N8O2
- Molecular Weight: 558.646
- Create Date: 2020-01-19 19:43:27
- Modify Date: 2024-11-29 18:55:56
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DB2115 is a small-molecule transcription factor PU.1 inhibitor abrogating DNA binding by PU.1 with Kd of 1.0 nM; decrease cell growth (IC50=3.4 uM) and the clonogenic capacity of AML cells and leads to increased apoptosis, while showing little effect on normal hematopoietic cells; decreases tumor burden and increases survival in murine and human AML transplantation models.
| Name | DB2115 |
|---|
| Description | DB2115 is a small-molecule transcription factor PU.1 inhibitor abrogating DNA binding by PU.1 with Kd of 1.0 nM; decrease cell growth (IC50=3.4 uM) and the clonogenic capacity of AML cells and leads to increased apoptosis, while showing little effect on normal hematopoietic cells; decreases tumor burden and increases survival in murine and human AML transplantation models. |
|---|---|
| References | References 1. Antony-Debré I, et al. J Clin Invest. 2017 Oct 30. pii: 92504. View Related Products by Target Other Targets |
| Molecular Formula | C32H30N8O2 |
|---|---|
| Molecular Weight | 558.646 |