1364269-10-2
1364269-10-2 structure
- Name: Nek2 inhibitor (R)-21
- Chemical Name: Nek2 inhibitor (R)-21
- CAS Number: 1364269-10-2
- Molecular Formula: C24H25F3N4O2S
- Molecular Weight: 490.545
- Create Date: 2020-01-12 11:39:04
- Modify Date: 2024-01-09 08:27:31
-
A potent and selective NIMA-related Kinase 2 (NEK2) inhibitor with IC50 of 22 nM, >200-fold selectivity over Plk1, Mps1, Aurora A and CDK2; also shows >100-fold selectivity over a panel of 24 kinases; down-regulates C-Nap1 phosphoryation with IC50 of 0.8 uM, shows antiproliferative effect on U2OS, MDA-MB-231, HeLa and MCF7 cell with GI50 of 1.82, 4.16, 0.59 and 2.17 uM, respectively; is a valuable tool for investigating the role of Nek2 in the cell cycle and its function in mitotic organization.
| Name | Nek2 inhibitor (R)-21 |
|---|
| Description | A potent and selective NIMA-related Kinase 2 (NEK2) inhibitor with IC50 of 22 nM, >200-fold selectivity over Plk1, Mps1, Aurora A and CDK2; also shows >100-fold selectivity over a panel of 24 kinases; down-regulates C-Nap1 phosphoryation with IC50 of 0.8 uM, shows antiproliferative effect on U2OS, MDA-MB-231, HeLa and MCF7 cell with GI50 of 1.82, 4.16, 0.59 and 2.17 uM, respectively; is a valuable tool for investigating the role of Nek2 in the cell cycle and its function in mitotic organization. |
|---|---|
| References | References 1. Innocenti P, et al. J Med Chem. 2012 Apr 12;55(7):3228-41. View Related Products by Target Hec1/Nek2 |
| Molecular Formula | C24H25F3N4O2S |
|---|---|
| Molecular Weight | 490.545 |