1331745-61-9
1331745-61-9 structure
- Name: ML372
- Chemical Name: ML372
- CAS Number: 1331745-61-9
- Molecular Formula: C18H20N2O4S
- Molecular Weight: 360.428
- Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA/RNA Synthesis
- Create Date: 2020-01-11 15:20:49
- Modify Date: 2024-08-13 19:44:50
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ML372 is a small molecule SMN modulator that increases SMN protein in patient fibroblasts with EC50 of 37 nM; possesses good potency, pharmacokinetics, tolerance, and CNS penetration that are able to increase levels of SMN protein in several model cell lines; increase SMN protein levels in vivo, restore motor function, and prolong survival of SMNΔ7 SMA Mice; improves the righting reflex and extended survival of a severe mouse model of SMA.
| Name | ML372 |
|---|
| Description | ML372 is a small molecule SMN modulator that increases SMN protein in patient fibroblasts with EC50 of 37 nM; possesses good potency, pharmacokinetics, tolerance, and CNS penetration that are able to increase levels of SMN protein in several model cell lines; increase SMN protein levels in vivo, restore motor function, and prolong survival of SMNΔ7 SMA Mice; improves the righting reflex and extended survival of a severe mouse model of SMA. |
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| References | References 1. Burnett BG, et al. Probe Reports from the NIH Molecular Libraries Program [Internet]. 2. Abera MB, et al. JCI Insight. 2016 Nov 17;1(19):e88427. View Related Products by Target SMN2 Modulator |
| Molecular Formula | C18H20N2O4S |
|---|---|
| Molecular Weight | 360.428 |