ML372
Modify Date: 2024-08-13 19:44:50
ML372 structure
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Common Name | ML372 | ||
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| CAS Number | 1331745-61-9 | Molecular Weight | 360.428 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H20N2O4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ML372ML372 is a small molecule SMN modulator that increases SMN protein in patient fibroblasts with EC50 of 37 nM; possesses good potency, pharmacokinetics, tolerance, and CNS penetration that are able to increase levels of SMN protein in several model cell lines; increase SMN protein levels in vivo, restore motor function, and prolong survival of SMNΔ7 SMA Mice; improves the righting reflex and extended survival of a severe mouse model of SMA. |
| Name | ML372 |
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| Description | ML372 is a small molecule SMN modulator that increases SMN protein in patient fibroblasts with EC50 of 37 nM; possesses good potency, pharmacokinetics, tolerance, and CNS penetration that are able to increase levels of SMN protein in several model cell lines; increase SMN protein levels in vivo, restore motor function, and prolong survival of SMNΔ7 SMA Mice; improves the righting reflex and extended survival of a severe mouse model of SMA. |
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| References | References 1. Burnett BG, et al. Probe Reports from the NIH Molecular Libraries Program [Internet]. 2. Abera MB, et al. JCI Insight. 2016 Nov 17;1(19):e88427. View Related Products by Target SMN2 Modulator |
| Molecular Formula | C18H20N2O4S |
|---|---|
| Molecular Weight | 360.428 |