1232841-78-9
1232841-78-9 structure
- Name: PBT434
- Chemical Name: PBT434
- CAS Number: 1232841-78-9
- Molecular Formula: C12H14BrCl2N3O2
- Molecular Weight: 383.067
- Create Date: 2020-01-20 19:18:56
- Modify Date: 2025-08-27 00:27:06
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PBT434 is a novel quinazolinone compound with effect of lowering cellular iron levels, prevents iron mediated neurodegeneration and α-synuclein toxicity in multiple models of Parkinson disease; inhibits iron-mediated redox activity and iron-mediated aggregation of α-synuclein, a protein that aggregates in the neuropathology; prevents loss of substantia nigra pars compacta neurons (SNpc), lowers nigral α-synuclein accumulation, and rescues motor performance in mice model of PD.
| Name | PBT434 |
|---|
| Description | PBT434 is a novel quinazolinone compound with effect of lowering cellular iron levels, prevents iron mediated neurodegeneration and α-synuclein toxicity in multiple models of Parkinson disease; inhibits iron-mediated redox activity and iron-mediated aggregation of α-synuclein, a protein that aggregates in the neuropathology; prevents loss of substantia nigra pars compacta neurons (SNpc), lowers nigral α-synuclein accumulation, and rescues motor performance in mice model of PD. |
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| References | References 1. Finkelstein DI, et al. Acta Neuropathol Commun. 2017 Jun 28;5(1):53. View Related Products by Target Other Targets |
| Molecular Formula | C12H14BrCl2N3O2 |
|---|---|
| Molecular Weight | 383.067 |