PBT434
Modify Date: 2025-08-27 00:27:06
PBT434 structure
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Common Name | PBT434 | ||
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| CAS Number | 1232841-78-9 | Molecular Weight | 383.067 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C12H14BrCl2N3O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PBT434PBT434 is a novel quinazolinone compound with effect of lowering cellular iron levels, prevents iron mediated neurodegeneration and α-synuclein toxicity in multiple models of Parkinson disease; inhibits iron-mediated redox activity and iron-mediated aggregation of α-synuclein, a protein that aggregates in the neuropathology; prevents loss of substantia nigra pars compacta neurons (SNpc), lowers nigral α-synuclein accumulation, and rescues motor performance in mice model of PD. |
| Name | PBT434 |
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| Description | PBT434 is a novel quinazolinone compound with effect of lowering cellular iron levels, prevents iron mediated neurodegeneration and α-synuclein toxicity in multiple models of Parkinson disease; inhibits iron-mediated redox activity and iron-mediated aggregation of α-synuclein, a protein that aggregates in the neuropathology; prevents loss of substantia nigra pars compacta neurons (SNpc), lowers nigral α-synuclein accumulation, and rescues motor performance in mice model of PD. |
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| References | References 1. Finkelstein DI, et al. Acta Neuropathol Commun. 2017 Jun 28;5(1):53. View Related Products by Target Other Targets |
| Molecular Formula | C12H14BrCl2N3O2 |
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| Molecular Weight | 383.067 |