1220476-13-0
1220476-13-0 structure
- Name: CSIC E379
- Chemical Name: CSIC E379
- CAS Number: 1220476-13-0
- Molecular Formula: C20H24O
- Molecular Weight: 280.411
- Create Date: 2020-01-11 17:54:49
- Modify Date: 2024-09-14 09:29:28
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CSIC E379 is a potent, selective uncoupling proteins UCP1/UCP2 inhibitor with EC50 of 20 uM/30 uM, respectively; does not affect OXPHOS system and membrane permeability in liver mitochondria; causes oxidative stress, inhibit the cellular respiration of the cancer cell line HT-29; increases the production of superoxide and decreases the cell viability; potentiates the efficacy of the cytotoxic drug arsenic trioxide.
| Name | CSIC E379 |
|---|
| Description | CSIC E379 is a potent, selective uncoupling proteins UCP1/UCP2 inhibitor with EC50 of 20 uM/30 uM, respectively; does not affect OXPHOS system and membrane permeability in liver mitochondria; causes oxidative stress, inhibit the cellular respiration of the cancer cell line HT-29; increases the production of superoxide and decreases the cell viability; potentiates the efficacy of the cytotoxic drug arsenic trioxide. |
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| References | References 1. Rial E, et al. Chem Biol. 2011 Feb 25;18(2):264-74. View Related Products by Target Other Targets |
| Molecular Formula | C20H24O |
|---|---|
| Molecular Weight | 280.411 |