1052515-37-3
1052515-37-3 structure
- Name: NSC 145366
- Chemical Name: NSC 145366
- CAS Number: 1052515-37-3
- Molecular Formula: C37H63ClN2O4
- Molecular Weight: 635.371
- Create Date: 2020-01-14 16:07:42
- Modify Date: 2024-04-06 12:01:40
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NSC 145366 is a novel, allosteric Hsp90 CTD (C-terminal domain) inhibitor, exhibits anti-proliferative activity in tumor cell lines with GI50 of 0.2-1.9 uM; increases Hsp90 oligomerization resulting in allosteric inhibition of NTD ATPase activity (IC50=119 uM), but does not compete with NTD or CTD-ATP binding; causes selective client protein downregulation including AR and BRCA1 but without a heat shock response in LNCaP prostate tumor cells.
| Name | NSC 145366 |
|---|
| Description | NSC 145366 is a novel, allosteric Hsp90 CTD (C-terminal domain) inhibitor, exhibits anti-proliferative activity in tumor cell lines with GI50 of 0.2-1.9 uM; increases Hsp90 oligomerization resulting in allosteric inhibition of NTD ATPase activity (IC50=119 uM), but does not compete with NTD or CTD-ATP binding; causes selective client protein downregulation including AR and BRCA1 but without a heat shock response in LNCaP prostate tumor cells. |
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| References | References 1. Thomas FM, et al. SLAS Discov. 2017 Jul;22(6):706-719. 2. Goode KM, et al. Biochim Biophys Acta. 2017 Aug;1861(8):1992-2006. View Related Products by Target Heat Shock Protein (HSP) |
| Molecular Formula | C37H63ClN2O4 |
|---|---|
| Molecular Weight | 635.371 |