1046490-67-8
1046490-67-8 structure
- Name: STA 2842
- Chemical Name: STA 2842
- CAS Number: 1046490-67-8
- Molecular Formula: C29H38N6O5
- Molecular Weight: 550.66
- Create Date: 2020-01-12 01:11:49
- Modify Date: 2025-08-30 19:40:13
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STA 2842 (STA2842) is a highly specific inhibitor of HSP90 (IC50=135 nM, HSP90α) that competitively binds the N-terminal ATP pocket of HSP90; induces the degradation of many ADPKD-relevant HSP90 client proteins in Pkd1(-/-) primary kidney cells and in vivo; significantly reduces initial formation of renal cysts and kidney growth and slows the progression of these phenotypes in mice with preexisting cysts.
| Name | STA 2842 |
|---|
| Description | STA 2842 (STA2842) is a highly specific inhibitor of HSP90 (IC50=135 nM, HSP90α) that competitively binds the N-terminal ATP pocket of HSP90; induces the degradation of many ADPKD-relevant HSP90 client proteins in Pkd1(-/-) primary kidney cells and in vivo; significantly reduces initial formation of renal cysts and kidney growth and slows the progression of these phenotypes in mice with preexisting cysts. |
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| References | References 1. Seeger-Nukpezah T, et al. Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12786-91. 2. Nikonova AS, et al. Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12859-64. 3. Smithline ZB, et al. PLoS One. 2014 Dec 4;9(12):e114403. View Related Products by Target Heat Shock Protein (HSP) |
| Molecular Formula | C29H38N6O5 |
|---|---|
| Molecular Weight | 550.66 |