2196243-57-7
2196243-57-7 structure
- Name: USP7-IN-4
- Chemical Name: USP7-IN-4
- CAS Number: 2196243-57-7
- Molecular Formula: C29H34N6O3
- Molecular Weight: 514.63
- Create Date: 2020-01-15 12:45:29
- Modify Date: 2024-01-11 08:47:35
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(R)-USP-IN-4 is a highly potent, selective, allosteric USP7 inhibitor with IC50 of 6 nM in FP assays; also shows high potency in an alternative assay using the Ub-Rh110 substrate (IC50=1.5 nM) and Kd of 2.0 nM; displays high selectivuty against other DUBs, proteases and kinases; demonstrates highly potent target engagement in cells (EC50=49 nM), with no off-target activity against USP47, causes nongenotoxic stabilization of p53 and decreased levels of MDM2 in HCT116 cells.
| Name | USP7-IN-4 |
|---|
| Description | (R)-USP-IN-4 is a highly potent, selective, allosteric USP7 inhibitor with IC50 of 6 nM in FP assays; also shows high potency in an alternative assay using the Ub-Rh110 substrate (IC50=1.5 nM) and Kd of 2.0 nM; displays high selectivuty against other DUBs, proteases and kinases; demonstrates highly potent target engagement in cells (EC50=49 nM), with no off-target activity against USP47, causes nongenotoxic stabilization of p53 and decreased levels of MDM2 in HCT116 cells. |
|---|---|
| References | References 1. Gavory G, et al. Nat Chem Biol. 2018 Feb;14(2):118-125. View Related Products by Target Deubiquitinase (DUB) |
| Molecular Formula | C29H34N6O3 |
|---|---|
| Molecular Weight | 514.63 |