2132410-88-7
2132410-88-7 structure
- Name: QD 325
- Chemical Name: QD 325
- CAS Number: 2132410-88-7
- Molecular Formula: C20H13N3O2
- Molecular Weight: 327.343
- Create Date: 2020-01-20 16:21:55
- Modify Date: 2024-09-22 18:40:58
-
QD325 is a potent redox modulator that induces Nrf2-mediated oxidative stress and unfolded protein responses in PDAC cells (IC50=0.9 uM); induces stress responses in nucleus, endoplasmic reticulum, and mitochondria of pancreatic cancer cells, dose-dependent increases in RNA synthesis of representative genes such as NQO1, HMOX1, DDIT3, and HSPA5, blocks mitochondrial function by inhibiting mtDNA transcription and downregulating the mtDNA-encoded OXPHOS enzymes; is well tolerated in vivo and significantly delayes tumor growth in mice.
| Name | QD 325 |
|---|
| Description | QD325 is a potent redox modulator that induces Nrf2-mediated oxidative stress and unfolded protein responses in PDAC cells (IC50=0.9 uM); induces stress responses in nucleus, endoplasmic reticulum, and mitochondria of pancreatic cancer cells, dose-dependent increases in RNA synthesis of representative genes such as NQO1, HMOX1, DDIT3, and HSPA5, blocks mitochondrial function by inhibiting mtDNA transcription and downregulating the mtDNA-encoded OXPHOS enzymes; is well tolerated in vivo and significantly delayes tumor growth in mice. |
|---|---|
| References | References 1. Kuang Y, et al. J Med Chem. 2018 Feb 22;61(4):1576-1594. View Related Products by Target Keap1-Nrf2 |
| Molecular Formula | C20H13N3O2 |
|---|---|
| Molecular Weight | 327.343 |