1097917-15-1

1097917-15-1 structure

Name: ASP3026
Chemical Name: 2-N-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]-4-N-(2-propan-2-ylsulfonylphenyl)-1,3,5-triazine-2,4-diamine
CAS Number: 1097917-15-1
Molecular Formula: C₂₉H₄₀N₈O₃S
Molecular Weight: 580.745
Catalog: Biochemical Inhibitor Protein tyrosine kinase
Create Date: 2016-09-18 10:15:15
Modify Date: 2024-01-02 12:26:26
ASP3026 is a novel and selective inhibitor for ALK (anaplastic lymphoma kinase) with IC50 of 3.5 nM.

Name	2-N-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]-4-N-(2-propan-2-ylsulfonylphenyl)-1,3,5-triazine-2,4-diamine
Synonyms	N2-[2-Methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-1,3,5-triazine-2,4-diamine cc-325 QCR-144 N-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}-N'-[2-(propane-2-sulfonyl)phenyl]-1,3,5-triazine-2,4-diamine ASP 3026 N-[2-(isopropylsulfonyl)phenyl]-N'-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}-1,3,5-triazine-2,4-diamine 1,3,5-Triazine-2,4-diamine, N-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N-[2-[(1-methylethyl)sulfonyl]phenyl]- CS-0787 UNII-HP4L6MXF10 N-[2-(Isopropylsulfonyl)phenyl]-N'-{2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl}-1,3,5-triazine-2,4-diamine ASP3026

Description	ASP3026 is a novel and selective inhibitor for ALK (anaplastic lymphoma kinase) with IC50 of 3.5 nM.
Related Catalog	Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ALK Research Areas >> Cancer
References	[1]. Sadao Kuromitsu, et al. AACR 102nd Annual Meeting, 2011.

Density	1.3±0.1 g/cm3
Boiling Point	794.3±70.0 °C at 760 mmHg
Molecular Formula	C₂₉H₄₀N₈O₃S
Molecular Weight	580.745
Flash Point	434.2±35.7 °C
Exact Mass	580.294434
PSA	127.43000
LogP	1.01
Vapour Pressure	0.0±2.8 mmHg at 25°C
Index of Refraction	1.620
Storage condition	-20°C

109-01-3

1097917-68-4

~85%

1097917-15-1

Literature: Astellas Pharma Inc.; OBITSU, Kazuyoshi; AKIBA, Takahiro; KOBAYASHI, Koji; HIRASAWA, Shun; KONDOH, Yutaka; TAKEGUCHI, Kazuhiro; TAKAHAMA, Yuji; ORII, Ryoki Patent: EP2669281 A1, 2013 ; Location in patent: Paragraph 0059 ;