1803242-21-8
1803242-21-8 structure
- Name: DJ101
- Chemical Name: DJ101
- CAS Number: 1803242-21-8
- Molecular Formula: C23H20N4O3
- Molecular Weight: 400.438
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Microtubule/Tubulin
- Create Date: 2020-01-19 20:13:57
- Modify Date: 2024-04-05 18:34:51
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A novel potent and metabolically stable tubulin inhibitor that can circumvent the drug efflux pumps responsible for multidrug resistance of existing tubulin inhibitors; demonstrates cytotoxicty in a panel of human metastatic melanoma cell lines harboring major clinically relevant mutations with IC50 of 7-10 nM, disrupts microtubule networks, suppresses anchorage-dependent melanoma colony formation, and impaires cancer cell migration; inhibits tumor growth and reduced lung metastasis in melanoma-bearing mice, also completely inhibits tumor growth in a paclitaxel-resistant xenograft mouse model.
| Name | DJ101 |
|---|
| Description | A novel potent and metabolically stable tubulin inhibitor that can circumvent the drug efflux pumps responsible for multidrug resistance of existing tubulin inhibitors; demonstrates cytotoxicty in a panel of human metastatic melanoma cell lines harboring major clinically relevant mutations with IC50 of 7-10 nM, disrupts microtubule networks, suppresses anchorage-dependent melanoma colony formation, and impaires cancer cell migration; inhibits tumor growth and reduced lung metastasis in melanoma-bearing mice, also completely inhibits tumor growth in a paclitaxel-resistant xenograft mouse model. |
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| References | References 1. Arnst KE, et al. Cancer Res. 2018 Jan 1;78(1):265-277. View Related Products by Target Microtubule/Tubulin |
| Molecular Formula | C23H20N4O3 |
|---|---|
| Molecular Weight | 400.438 |