DJ101
Modify Date: 2025-08-22 08:35:57
DJ101 structure
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Common Name | DJ101 | ||
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| CAS Number | 1803242-21-8 | Molecular Weight | 400.438 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H20N4O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of DJ101A novel potent and metabolically stable tubulin inhibitor that can circumvent the drug efflux pumps responsible for multidrug resistance of existing tubulin inhibitors; demonstrates cytotoxicty in a panel of human metastatic melanoma cell lines harboring major clinically relevant mutations with IC50 of 7-10 nM, disrupts microtubule networks, suppresses anchorage-dependent melanoma colony formation, and impaires cancer cell migration; inhibits tumor growth and reduced lung metastasis in melanoma-bearing mice, also completely inhibits tumor growth in a paclitaxel-resistant xenograft mouse model. |
| Name | DJ101 |
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| Description | A novel potent and metabolically stable tubulin inhibitor that can circumvent the drug efflux pumps responsible for multidrug resistance of existing tubulin inhibitors; demonstrates cytotoxicty in a panel of human metastatic melanoma cell lines harboring major clinically relevant mutations with IC50 of 7-10 nM, disrupts microtubule networks, suppresses anchorage-dependent melanoma colony formation, and impaires cancer cell migration; inhibits tumor growth and reduced lung metastasis in melanoma-bearing mice, also completely inhibits tumor growth in a paclitaxel-resistant xenograft mouse model. |
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| References | References 1. Arnst KE, et al. Cancer Res. 2018 Jan 1;78(1):265-277. View Related Products by Target Microtubule/Tubulin |
| Molecular Formula | C23H20N4O3 |
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| Molecular Weight | 400.438 |