742112-34-1
742112-34-1 structure
- Name: OSU-03013
- Chemical Name: 2-{4-[5-(2-Phenanthryl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}guanidine
- CAS Number: 742112-34-1
- Molecular Formula: C25H18F3N5
- Molecular Weight: 445.439
- Create Date: 2020-01-11 11:53:53
- Modify Date: 2025-08-25 15:15:05
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OSU-03013 (OSU 03013, OSU03013) is a novel potent, orally active 3-phosphoinositide-dependent kinase-1 (PDK-1) with IC50 of 2 uM; induces apoptosis in PC-3 cells at low microM range, causes Akt dephosphorylation and inhibition of p70 S6 kinase activity; displays cytotocixity against a panel of 60 cell lines with mean GI50 of 3 uM.
| Name | 2-{4-[5-(2-Phenanthryl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}guanidine |
|---|---|
| Synonyms |
2-{4-[5-(2-Phenanthryl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}guanidine
Guanidine, N''-[4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]- |
| Description | OSU-03013 (OSU 03013, OSU03013) is a novel potent, orally active 3-phosphoinositide-dependent kinase-1 (PDK-1) with IC50 of 2 uM; induces apoptosis in PC-3 cells at low microM range, causes Akt dephosphorylation and inhibition of p70 S6 kinase activity; displays cytotocixity against a panel of 60 cell lines with mean GI50 of 3 uM. |
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| References | References 1. Baryawno N, et al. Cancer Res. 2010 Jan 1;70(1):266-76. View Related Products by Target PDK1 |
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 654.8±65.0 °C at 760 mmHg |
| Molecular Formula | C25H18F3N5 |
| Molecular Weight | 445.439 |
| Flash Point | 349.8±34.3 °C |
| Exact Mass | 445.151428 |
| LogP | 6.42 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Index of Refraction | 1.667 |