1539296-45-1
1539296-45-1 structure
- Name: PF-470
- Chemical Name: PF-06297470
- CAS Number: 1539296-45-1
- Molecular Formula: C18H16N6O
- Molecular Weight: 332.359
- Create Date: 2020-01-12 05:59:00
- Modify Date: 2024-01-16 17:19:31
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A highly potent, selective, and efficacious metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator with Ki of 0.9 nM, IC50 of 2.5 nM; demonstrates robust efficacy in MPTP-rendered Parkinsonian nonhuman primate model of l-DOPA-induced dyskinesia (PD-LID), but with delayed-type immune-mediated type IV hypersensitivity.
| Name | PF-06297470 |
|---|---|
| Synonyms |
1-Methyl-3-(4-methyl-3-pyridinyl)-6-(2-pyridinylmethoxy)-1H-pyrazolo[3,4-b]pyrazine
PF-06297470 MFCD28100803 1H-Pyrazolo[3,4-b]pyrazine, 1-methyl-3-(4-methyl-3-pyridinyl)-6-(2-pyridinylmethoxy)- |
| Description | A highly potent, selective, and efficacious metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator with Ki of 0.9 nM, IC50 of 2.5 nM; demonstrates robust efficacy in MPTP-rendered Parkinsonian nonhuman primate model of l-DOPA-induced dyskinesia (PD-LID), but with delayed-type immune-mediated type IV hypersensitivity. |
|---|---|
| References | References 1. Zhang L, et al. J Med Chem. 2014 Feb 13;57(3):861-77. View Related Products by Target mGluR |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 526.8±45.0 °C at 760 mmHg |
| Molecular Formula | C18H16N6O |
| Molecular Weight | 332.359 |
| Flash Point | 272.4±28.7 °C |
| Exact Mass | 332.138550 |
| LogP | 1.13 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.699 |
