1330781-04-8

1330781-04-8 structure

Name: Cdc7 inhibitor 7c
Chemical Name: 6-(3-Methyl-1H-pyrazol-4-yl)-2-(1-pyrrolidinylmethyl)thieno[3,2-d]pyrimidin-4(3H)-one
CAS Number: 1330781-04-8
Molecular Formula: C₁₅H₁₇N₅OS
Molecular Weight: 315.393
Create Date: 2020-01-12 11:29:58
Modify Date: 2025-08-23 00:54:19
A highly potent, selective and time-dependent Cdc7 kinase inhibitor with IC50 of 0.7 nM with slow dissociation property, with 200-fold and >14,000-fold selectivity over CDK2 and ROCK1, respectively; exhibits significant time-dependent Cdc7 inhibition with slow dissociation kinetics, cellular pharmacodynamic (PD) effects, and COLO205 growth inhibition.

Name	6-(3-Methyl-1H-pyrazol-4-yl)-2-(1-pyrrolidinylmethyl)thieno[3,2-d]pyrimidin-4(3H)-one
Synonyms	6-(3-Methyl-1H-pyrazol-4-yl)-2-(1-pyrrolidinylmethyl)thieno[3,2-d]pyrimidin-4(3H)-one Thieno[3,2-d]pyrimidin-4(3H)-one, 6-(3-methyl-1H-pyrazol-4-yl)-2-(1-pyrrolidinylmethyl)-

Description	A highly potent, selective and time-dependent Cdc7 kinase inhibitor with IC50 of 0.7 nM with slow dissociation property, with 200-fold and >14,000-fold selectivity over CDK2 and ROCK1, respectively; exhibits significant time-dependent Cdc7 inhibition with slow dissociation kinetics, cellular pharmacodynamic (PD) effects, and COLO205 growth inhibition.
References	References 1. Kurasawa O, et al. Bioorg Med Chem. 2017 Jul 15;25(14):3658-3670. View Related Products by Target Cyclin-dependent Kinase (CDK)