1246202-11-8

1246202-11-8 structure

Name: SN-32976
Chemical Name: 2-[(4-{4-[2-(Difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl}-1-piperazinyl)sulfonyl]-N,N-dimethylethanamine
CAS Number: 1246202-11-8
Molecular Formula: C₂₄H₃₃F₂N₉O₄S
Molecular Weight: 581.638
Create Date: 2020-01-12 17:21:01
Modify Date: 2025-08-25 18:54:55
SN-32976 is a novel, potent and selective class I PI3K and mTOR inhibitor with IC50 of 15.1/461/110/134/194 nM for PI3Kα/PI3Kβ/PI3Kγ/PI3Kδ/mTOR, respectively; displays preferential activity for PI3Kα and spares PI3Kδ relative to the other inhibitors, and shows less off-target activity in a panel of 442 kinases; inhibits pAKT expression and cell proliferation at nM concentration, induces a greater extent and duration of pAKT inhibition in tumors than pictilisib, dactolisib and omipalisib in animal models.

Name	2-[(4-{4-[2-(Difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl}-1-piperazinyl)sulfonyl]-N,N-dimethylethanamine
Synonyms	2-[(4-{4-[2-(Difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl}-1-piperazinyl)sulfonyl]-N,N-dimethylethanamine Ethanamine, 2-[[4-[4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-1-piperazinyl]sulfonyl]-N,N-dimethyl-

Description	SN-32976 is a novel, potent and selective class I PI3K and mTOR inhibitor with IC50 of 15.1/461/110/134/194 nM for PI3Kα/PI3Kβ/PI3Kγ/PI3Kδ/mTOR, respectively; displays preferential activity for PI3Kα and spares PI3Kδ relative to the other inhibitors, and shows less off-target activity in a panel of 442 kinases; inhibits pAKT expression and cell proliferation at nM concentration, induces a greater extent and duration of pAKT inhibition in tumors than pictilisib, dactolisib and omipalisib in animal models.
References	References 1. Rewcastle GW, et al. Oncotarget. 2017 May 9. doi: 10.18632/oncotarget.17730. View Related Products by Target PI3K