948845-91-8
948845-91-8 structure
- Name: ABT-288
- Chemical Name: ABT-288
- CAS Number: 948845-91-8
- Molecular Formula: C23H24N4O
- Molecular Weight: 372.463
- Create Date: 2020-01-12 12:11:52
- Modify Date: 2024-01-12 22:41:47
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ABT-288 is a potent, selective and competitive antagonist of H3 receptor with Ki of 1.9/8.2 nM for human/rat H3 respectively; enhances the release of acetylcholine and dopamine in rat prefrontal cortex; possesses excellent pharmacokinetics and oral bioavailability.
| Name | ABT-288 |
|---|---|
| Synonyms |
ABT-288
2-{4'-[(3aR,6aR)-5-Methylhexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl]-4-biphenylyl}-3(2H)-pyridazinone 3(2H)-Pyridazinone, 2-[4'-[(3aR,6aR)-hexahydro-5-methylpyrrolo[3,4-b]pyrrol-1(2H)-yl][1,1'-biphenyl]-4-yl]- 5MEI1M3NHH |
| Description | ABT-288 is a potent, selective and competitive antagonist of H3 receptor with Ki of 1.9/8.2 nM for human/rat H3 respectively; enhances the release of acetylcholine and dopamine in rat prefrontal cortex; possesses excellent pharmacokinetics and oral bioavailability. |
|---|---|
| References | References 1. Esbenshade TA, et al. J Pharmacol Exp Ther. 2012 Oct;343(1):233-45. 2. Hudzik TJ, et al. Psychopharmacology (Berl). 2013 Jul;228(2):187-97. 3. Othman AA, et al. Br J Clin Pharmacol. 2014 Jun;77(6):965-74. View Related Products by Target Histamine Receptor |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 567.4±60.0 °C at 760 mmHg |
| Molecular Formula | C23H24N4O |
| Molecular Weight | 372.463 |
| Flash Point | 296.9±32.9 °C |
| Exact Mass | 372.195007 |
| LogP | 2.72 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.683 |