931314-31-7

931314-31-7 structure

Name: SPA70
Chemical Name: 1-(2,5-Dimethoxyphenyl)-5-methyl-4-{[4-(2-methyl-2-propanyl)phenyl]sulfonyl}-1H-1,2,3-triazole
CAS Number: 931314-31-7
Molecular Formula: C₂₁H₂₅N₃O₄S
Molecular Weight: 415.506
Catalog: Research Areas Cancer
Create Date: 2020-01-12 08:04:15
Modify Date: 2025-08-26 15:30:14
SPA70 is a potent and selective hPXR antagonist (IC50=0.51 uM) that interacts with the ligand-binding domain (LBD) of hPXR, inhibits hPXR in human hepatocytes and mouse models and enhances the chemosensitivity of cancer cells; displays highly selectivity over 10 other nuclear receptors (FXR, LXR, RXR, PPAR, etc.); antagonizes hPXR target genes induced by various hPXR agonists, blocks hPXR-mediated drug metabolism in vivo.

Name	1-(2,5-Dimethoxyphenyl)-5-methyl-4-{[4-(2-methyl-2-propanyl)phenyl]sulfonyl}-1H-1,2,3-triazole
Synonyms	MFCD14774311 1H-1,2,3-Triazole, 1-(2,5-dimethoxyphenyl)-4-[[4-(1,1-dimethylethyl)phenyl]sulfonyl]-5-methyl- 1-(2,5-Dimethoxyphenyl)-5-methyl-4-{[4-(2-methyl-2-propanyl)phenyl]sulfonyl}-1H-1,2,3-triazole

Description	SPA70 is a potent and selective hPXR antagonist (IC50=0.51 uM) that interacts with the ligand-binding domain (LBD) of hPXR, inhibits hPXR in human hepatocytes and mouse models and enhances the chemosensitivity of cancer cells; displays highly selectivity over 10 other nuclear receptors (FXR, LXR, RXR, PPAR, etc.); antagonizes hPXR target genes induced by various hPXR agonists, blocks hPXR-mediated drug metabolism in vivo.
References	References 1. Lin W, et al. Nat Commun. 2017 Sep 29;8(1):741. View Related Products by Target Pregnane X Receptor (PXR)