SPA70
Modify Date: 2025-08-26 15:30:14
SPA70 structure
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Common Name | SPA70 | ||
|---|---|---|---|---|
| CAS Number | 931314-31-7 | Molecular Weight | 415.506 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 612.6±65.0 °C at 760 mmHg | |
| Molecular Formula | C21H25N3O4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 324.3±34.3 °C | |
Use of SPA70SPA70 is a potent and selective hPXR antagonist (IC50=0.51 uM) that interacts with the ligand-binding domain (LBD) of hPXR, inhibits hPXR in human hepatocytes and mouse models and enhances the chemosensitivity of cancer cells; displays highly selectivity over 10 other nuclear receptors (FXR, LXR, RXR, PPAR, etc.); antagonizes hPXR target genes induced by various hPXR agonists, blocks hPXR-mediated drug metabolism in vivo. |
| Name | 1-(2,5-Dimethoxyphenyl)-5-methyl-4-{[4-(2-methyl-2-propanyl)phenyl]sulfonyl}-1H-1,2,3-triazole |
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| Synonym | More Synonyms |
| Description | SPA70 is a potent and selective hPXR antagonist (IC50=0.51 uM) that interacts with the ligand-binding domain (LBD) of hPXR, inhibits hPXR in human hepatocytes and mouse models and enhances the chemosensitivity of cancer cells; displays highly selectivity over 10 other nuclear receptors (FXR, LXR, RXR, PPAR, etc.); antagonizes hPXR target genes induced by various hPXR agonists, blocks hPXR-mediated drug metabolism in vivo. |
|---|---|
| References | References 1. Lin W, et al. Nat Commun. 2017 Sep 29;8(1):741. View Related Products by Target Pregnane X Receptor (PXR) |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 612.6±65.0 °C at 760 mmHg |
| Molecular Formula | C21H25N3O4S |
| Molecular Weight | 415.506 |
| Flash Point | 324.3±34.3 °C |
| Exact Mass | 415.156586 |
| LogP | 4.01 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.586 |
| InChIKey | OIOPHIFJQXHPAF-UHFFFAOYSA-N |
| SMILES | COc1ccc(OC)c(-n2nnc(S(=O)(=O)c3ccc(C(C)(C)C)cc3)c2C)c1 |
| MFCD14774311 |
| 1H-1,2,3-Triazole, 1-(2,5-dimethoxyphenyl)-4-[[4-(1,1-dimethylethyl)phenyl]sulfonyl]-5-methyl- |
| 1-(2,5-Dimethoxyphenyl)-5-methyl-4-{[4-(2-methyl-2-propanyl)phenyl]sulfonyl}-1H-1,2,3-triazole |