712325-30-9
712325-30-9 structure
- Name: VU0405601
- Chemical Name: vu0405601
- CAS Number: 712325-30-9
- Molecular Formula: C17H13BrN2O2
- Molecular Weight: 357.201
- Create Date: 2020-01-12 11:02:34
- Modify Date: 2025-08-26 08:30:42
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A potent Kv11.1 (hERG) channel allosteric modulator that protects cardiac tissue from hERG-related drug-induced arrhythmias; increases the IC(50) of dofetilide from 38.7 to 76.3 nM, mitigates the effects of hERG blockers from the extracellular aspect primarily by reducing inactivation; reduces the sensitivity of hERG to inhibitors.
| Name | vu0405601 |
|---|---|
| Synonyms |
2-[(1-bromonaphthalen-2-yl)oxy]-N-(pyridin-3-yl)acetamide
Acetamide, 2-[(1-bromo-2-naphthalenyl)oxy]-N-3-pyridinyl- MFCD05995040 vu0405601 2-[(1-Bromo-2-naphthyl)oxy]-N-(3-pyridinyl)acetamide 2-[(1-Bromo-2-naphthalenyl)oxy]-N-3-pyridinyl-acetamide |
| Description | A potent Kv11.1 (hERG) channel allosteric modulator that protects cardiac tissue from hERG-related drug-induced arrhythmias; increases the IC(50) of dofetilide from 38.7 to 76.3 nM, mitigates the effects of hERG blockers from the extracellular aspect primarily by reducing inactivation; reduces the sensitivity of hERG to inhibitors. |
|---|---|
| References | References 1. Potet F, et al. J Biol Chem. 2012 Nov 16;287(47):39613-25. 2. Yu Z, et al. Circ Arrhythm Electrophysiol. 2016 Apr;9(4):e003439. View Related Products by Target Potassium Channel |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 584.8±35.0 °C at 760 mmHg |
| Molecular Formula | C17H13BrN2O2 |
| Molecular Weight | 357.201 |
| Flash Point | 307.5±25.9 °C |
| Exact Mass | 356.016022 |
| LogP | 3.71 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.698 |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| RIDADR | NONH for all modes of transport |