47208-82-2
47208-82-2 structure
- Name: 5MPN
- Chemical Name: MFCD00089445
- CAS Number: 47208-82-2
- Molecular Formula: C15H19N3O4
- Molecular Weight: 305.329
- Catalog: Research Areas Cancer
- Create Date: 2020-01-11 16:10:31
- Modify Date: 2025-08-25 18:41:24
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5MPN is a first-in-class, selective, competitive, orally available inhibitor of PFKFB4 with Ki of 8.6 uM, does not inhibit PFK-1 or PFKFB3; suppresses the glycolysis and proliferation of multiple human cancer cell lines but not non-transformed epithelial cells in vitro, suppresses the glucose metabolism and growth of tumors in mice.
| Name | MFCD00089445 |
|---|---|
| Synonyms |
5-[(8-Methoxy-4-quinolinyl)amino]pentyl nitrate
MFCD00089445 5-(N-(8-METHOXY-4-QUINOLYL)AMINO)PENTYL NITRATE 1-Pentanol, 5-[(8-methoxy-4-quinolinyl)amino]-, nitrate (ester) |
| Description | 5MPN is a first-in-class, selective, competitive, orally available inhibitor of PFKFB4 with Ki of 8.6 uM, does not inhibit PFK-1 or PFKFB3; suppresses the glycolysis and proliferation of multiple human cancer cell lines but not non-transformed epithelial cells in vitro, suppresses the glucose metabolism and growth of tumors in mice. |
|---|---|
| References | References 1. Chesney J, et al. Oncotarget. 2015 Jul 20;6(20):18001-11. View Related Products by Target Other Targets |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 493.8±40.0 °C at 760 mmHg |
| Molecular Formula | C15H19N3O4 |
| Molecular Weight | 305.329 |
| Flash Point | 252.4±27.3 °C |
| Exact Mass | 305.137543 |
| LogP | 3.59 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.607 |
| Hazard Codes | Xi |
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