1810051-96-7
1810051-96-7 structure
- Name: LYS228
- Chemical Name: 29H7N9ξ1B
- CAS Number: 1810051-96-7
- Molecular Formula: C16H18N6O10S2
- Molecular Weight: 518.478
- Catalog: Signaling Pathways Anti-infection Bacterial
- Create Date: 2020-01-20 18:30:56
- Modify Date: 2024-01-02 10:00:15
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LYS228 is a novel potent monobactam that shows potent activity against carbapenem-resistant isolates of Enterobacteriaceae with MIC90 of 2 ug/ml; LYS228 is stable against Metallo-β-lactamases (MBLs), and shows small or no MIC shifts for most SBLs (serine β-lactamases), including CTX-Ms, KPCs and OXA-types. Bacterial Infection Phase 2 Clinical
| Name | 29H7N9ξ1B |
|---|---|
| Synonyms |
1-({(Z)-[1-(2-Amino-1,3-thiazol-4-yl)-2-oxo-2-({(3S,4R)-2-oxo-4-[(2-oxo-1,3-oxazolidin-3-yl)methyl]-1-sulfo-3-azetidinyl}amino)ethylidene]amino}oxy)cyclopropanecarboxylic acid
29H7N9ξ1B Cyclopropanecarboxylic acid, 1-[[[(1Z)-1-(2-amino-4-thiazolyl)-2-oxo-2-[[(3S,4R)-2-oxo-4-[(2-oxo-3-oxazolidinyl)methyl]-1-sulfo-3-azetidinyl]amino]ethylidene]amino]oxy]- |
| Description | LYS228 is a novel potent monobactam that shows potent activity against carbapenem-resistant isolates of Enterobacteriaceae with MIC90 of 2 ug/ml; LYS228 is stable against Metallo-β-lactamases (MBLs), and shows small or no MIC shifts for most SBLs (serine β-lactamases), including CTX-Ms, KPCs and OXA-types. Bacterial Infection Phase 2 Clinical |
|---|---|
| References | References 1. Reck F, et al. Bioorg Med Chem Lett. 2018 Feb 15;28(4):748-755. View Related Products by Target Bacterial Bacterial Infection |
| Density | 2.1±0.1 g/cm3 |
|---|---|
| Molecular Formula | C16H18N6O10S2 |
| Molecular Weight | 518.478 |
| Exact Mass | 518.052551 |
| LogP | -2.12 |
| Index of Refraction | 1.867 |