1627900-41-7
1627900-41-7 structure
- Name: JNJ 54166060
- Chemical Name: [2-Chloro-3-(trifluoromethyl)phenyl][(4R)-1-(5-fluoro-2-pyridinyl)-4-methyl-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]methanone
- CAS Number: 1627900-41-7
- Molecular Formula: C20H15ClF4N4O
- Molecular Weight: 438.806
- Create Date: 2020-01-12 01:26:49
- Modify Date: 2024-07-17 15:26:56
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A potent, selective and orally bioavailable P2X7 receptor with IC50 of 4 nM and 115 nM for hP2X7 and rP2X7, respectively; also is a potent inhibitor of CYP3A with IC50 of 2 uM, exhibits dose dependent occupancy in the rat brain with an ED50 of 2.3 mg/kg.
| Name | [2-Chloro-3-(trifluoromethyl)phenyl][(4R)-1-(5-fluoro-2-pyridinyl)-4-methyl-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]methanone |
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| Synonyms |
[2-Chloro-3-(trifluoromethyl)phenyl][(4R)-1-(5-fluoro-2-pyridinyl)-4-methyl-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]methanone
Methanone, [2-chloro-3-(trifluoromethyl)phenyl][(4R)-1-(5-fluoro-2-pyridinyl)-1,4,6,7-tetrahydro-4-methyl-5H-imidazo[4,5-c]pyridin-5-yl]- MFCD30530737 |
| Description | A potent, selective and orally bioavailable P2X7 receptor with IC50 of 4 nM and 115 nM for hP2X7 and rP2X7, respectively; also is a potent inhibitor of CYP3A with IC50 of 2 uM, exhibits dose dependent occupancy in the rat brain with an ED50 of 2.3 mg/kg. |
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| References | References 1. Swanson DM, et al. J Med Chem. 2016 Sep 22;59(18):8535-48. View Related Products by Target P2X Receptor |
| Density | 1.5±0.1 g/cm3 |
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| Boiling Point | 586.7±50.0 °C at 760 mmHg |
| Molecular Formula | C20H15ClF4N4O |
| Molecular Weight | 438.806 |
| Flash Point | 308.7±30.1 °C |
| Exact Mass | 438.087067 |
| LogP | 4.50 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.624 |