203192-01-2
203192-01-2 structure
- Name: MN58b
- Chemical Name: MN58b
- CAS Number: 203192-01-2
- Molecular Formula: C32H40Br2N4
- Molecular Weight: 640.49
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2019-12-07 13:07:54
- Modify Date: 2024-01-06 17:29:20
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MN58b is a selective choline kinase α (CHKα) inhibitor, and results in inhibition of phosphocholine synthesis. MN58b reduces cell growth through the induction of apoptosis, and also has antitumoral activity[1][2].
| Name | MN58b |
|---|
| Description | MN58b is a selective choline kinase α (CHKα) inhibitor, and results in inhibition of phosphocholine synthesis. MN58b reduces cell growth through the induction of apoptosis, and also has antitumoral activity[1][2]. |
|---|---|
| Related Catalog | |
| Target |
Choline kinase α (CHKα)[1] |
| In Vitro | The IC50s of MN58b for parental and Gemcitabine-resistant Suit2 007 cells are 3.14 µM and 0.77 µM, respectively[1]. MN58b (1-5 µM; 72 hours; SK-PC-1, Suit2 008, IMIM-PC2, and RWP-1 cells) has a marked effect on colony formation at 1 µM, and growth is completely abolished at 5 µM in all the cell lines[1]. MN58b ((1-10 µM; 24-48 hours; SK-PC-1, Suit2 008, IMIM-PC2, and RWP-1 cells) induces apoptosis and this response correlates with CHKα expression[1]. Cell Viability Assay[1] Cell Line: SK-PC-1, Suit2 008, IMIM-PC2, and RWP-1 cells Concentration: 1 µM, 5 µM Incubation Time: 72 hours Result: Inhibited cells growth. Apoptosis Analysis[1] Cell Line: SK-PC-1, Suit2 008, IMIM-PC2, and RWP-1 cells Concentration: 1 µM, 2 µM, 5 µM, 10 µM Incubation Time: 24 and 48 hours Result: Induced cell apoptosis. |
| In Vivo | MN58b (4 mg/kg; intraperitoneal injection; once a day; for 5 days; MF-1 nude mice) treatment significantly decreases phosphomonoesters in both HT29 and MDA-MB-231 xenografts. Phosphocholine levels are found to correlate with choline kinase activities[2]. Animal Model: MF-1 nude mice with HT29 or MDA-MB-231 cells[2] Dosage: 4 mg/kg Administration: Intraperitoneal injection; once a day; for 5 days Result: Phosphomonoesters decreased significantly. |
| References |
| Molecular Formula | C32H40Br2N4 |
|---|---|
| Molecular Weight | 640.49 |
| Hazard Codes | Xi |
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