1410809-36-7

1410809-36-7 structure

Name: ACHN-975
Chemical Name: ACHN-975
CAS Number: 1410809-36-7
Molecular Formula: C₂₀H₂₃N₃O₄
Molecular Weight: 369.41
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2019-12-07 15:37:54
Modify Date: 2025-08-26 15:18:38
ACHN-975 is a selective LpxC inhibitor, exhibiting a subnanomolar LpxC inhibitory activity and low MIC values (≤1 μg/mL) against a wide range of Gram-negative bacteria. LpxC is highly conserved in Gram-negative bacteria and catalyzes the first committed step of lipid A biosynthesis[1]. LpxC is the bacterial enzyme Zinc-dependent metalloamidase UDP-3-O-[(R)-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase[1].

Name	ACHN-975
Synonyms	MFCD29991590

Description	ACHN-975 is a selective LpxC inhibitor, exhibiting a subnanomolar LpxC inhibitory activity and low MIC values (≤1 μg/mL) against a wide range of Gram-negative bacteria. LpxC is highly conserved in Gram-negative bacteria and catalyzes the first committed step of lipid A biosynthesis[1]. LpxC is the bacterial enzyme Zinc-dependent metalloamidase UDP-3-O-[(R)-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
Target	LpxC[1]
In Vitro	ACHN-975 is against Enterobacteriaceae spp with an IC50 of 0.02 nM[1]. ACHN-975 is against Enterobacteriaceae spp, Pa, and Ab with MIC90 values of 1, 0.5, and >64 μg/mL, respectively[1].
References	[1]. Kalinin DV, et al. Insights into the Zinc-Dependent Deacetylase LpxC: Biochemical Properties and Inhibitor Design. Curr Top Med Chem. 2016;16(21):2379-430.

Molecular Formula	C₂₀H₂₃N₃O₄
Molecular Weight	369.41

Hazard Codes	Xi