2165322-94-9

2165322-94-9 structure

Name: USP25 and 28 inhibitor AZ-1
Chemical Name: USP25/28 inhibitor AZ1
CAS Number: 2165322-94-9
Molecular Formula: C₁₇H₁₆BrF₄NO₂
Molecular Weight: 422.21
Catalog: Signaling Pathways Cell Cycle/DNA Damage Deubiquitinase
Create Date: 2019-10-09 12:24:29
Modify Date: 2024-01-03 10:31:49
USP25/28 inhibitor AZ1 (AZ1) is a potent, selective, noncompetitive, dual ubiquitin specific protease (USP) 25/28 inhibitor with IC50s of 0.7 μM and 0.6 μM, respectively. USP25/28 inhibitor AZ1 reduces cell viability across a range of cancer cell lines[1].

Name	USP25/28 inhibitor AZ1

Description	USP25/28 inhibitor AZ1 (AZ1) is a potent, selective, noncompetitive, dual ubiquitin specific protease (USP) 25/28 inhibitor with IC50s of 0.7 μM and 0.6 μM, respectively. USP25/28 inhibitor AZ1 reduces cell viability across a range of cancer cell lines[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Deubiquitinase
Target	IC50: 0.7 nM (USP25) and 0.6 nM (USP28)[1]
References	[1]. Wrigley JD, et al. Identification and Characterization of Dual Inhibitors of the USP25/28 Deubiquitinating EnzymeSubfamily. ACS Chem Biol. 2017 Dec 15;12(12):3113-3125.

Molecular Formula	C₁₇H₁₆BrF₄NO₂
Molecular Weight	422.21