1890169-95-5

1890169-95-5 structure

Name: UPGL00004
Chemical Name: UPGL00004
CAS Number: 1890169-95-5
Molecular Formula: C₂₅H₂₆N₈O₂S₂
Molecular Weight: 534.66
Catalog: Research Areas Cancer
Create Date: 2019-10-08 17:34:52
Modify Date: 2024-01-05 15:28:50
UPGL00004 is a potent allosteric glutaminase C (GAC) inhibitor (IC50=29 nM; Kd=27 nM). UPGL00004 strongly inhibits the proliferation of highly aggressive triple-negative breast cancer cell lines[1].

Name	UPGL00004

Description	UPGL00004 is a potent allosteric glutaminase C (GAC) inhibitor (IC50=29 nM; Kd=27 nM). UPGL00004 strongly inhibits the proliferation of highly aggressive triple-negative breast cancer cell lines[1].
Related Catalog	Research Areas >> Cancer
Target	IC50: 29 nM (Glutaminase C)[1] Kd: 27 nM (Glutaminase C)[1]
In Vitro	UPGL00004 inhibits MDA-MB-231, HS578T and TSE cells with IC50s of 70, 129, and 262 nM, respectively[1].
In Vivo	The combination of UPGL00004 (1 mg/kg body weight) and Bevacizumab (2.5 mg/kg body weight) via intraperitoneal injection completely prevent any detectable increase in tumor size in a triple-negative breast cancer patient-derived tumor graft model[1].
References	[1]. Huang Q, et al. Characterization of the interactions of potent allosteric inhibitors with glutaminase C, a key enzyme in cancer cell glutamine metabolism. J Biol Chem. 2018 Mar 9;293(10):3535-3545.