UPGL00004
Modify Date: 2024-01-05 15:28:50
UPGL00004 structure
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Common Name | UPGL00004 | ||
|---|---|---|---|---|
| CAS Number | 1890169-95-5 | Molecular Weight | 534.66 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H26N8O2S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of UPGL00004UPGL00004 is a potent allosteric glutaminase C (GAC) inhibitor (IC50=29 nM; Kd=27 nM). UPGL00004 strongly inhibits the proliferation of highly aggressive triple-negative breast cancer cell lines[1]. |
| Name | UPGL00004 |
|---|
| Description | UPGL00004 is a potent allosteric glutaminase C (GAC) inhibitor (IC50=29 nM; Kd=27 nM). UPGL00004 strongly inhibits the proliferation of highly aggressive triple-negative breast cancer cell lines[1]. |
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| Related Catalog | |
| Target |
IC50: 29 nM (Glutaminase C)[1] Kd: 27 nM (Glutaminase C)[1] |
| In Vitro | UPGL00004 inhibits MDA-MB-231, HS578T and TSE cells with IC50s of 70, 129, and 262 nM, respectively[1]. |
| In Vivo | The combination of UPGL00004 (1 mg/kg body weight) and Bevacizumab (2.5 mg/kg body weight) via intraperitoneal injection completely prevent any detectable increase in tumor size in a triple-negative breast cancer patient-derived tumor graft model[1]. |
| References |
| Molecular Formula | C25H26N8O2S2 |
|---|---|
| Molecular Weight | 534.66 |
| Storage condition | -20°C |