2126819-55-2

2126819-55-2 structure

Name: Desmethyl-QCA276
Chemical Name: PROTAC BRD4-binding moiety 4
CAS Number: 2126819-55-2
Molecular Formula: C₂₁H₁₇N₅OS
Molecular Weight: 387.46
Catalog: Research Areas Cancer
Create Date: 2019-10-08 08:33:52
Modify Date: 2025-09-05 09:23:44
PROTAC BRD4-binding moiety 4 (compound 22) is a BET inhibitor with an IC50 of 10 nM, and with a Ki of 2.3 nM. PROTAC BRD4-binding moiety 4 is a BET ligand for PROTAC which is an extremely potent BET degrader[1].

Name	PROTAC BRD4-binding moiety 4

Description	PROTAC BRD4-binding moiety 4 (compound 22) is a BET inhibitor with an IC50 of 10 nM, and with a Ki of 2.3 nM. PROTAC BRD4-binding moiety 4 is a BET ligand for PROTAC which is an extremely potent BET degrader[1].
Related Catalog	Research Areas >> Cancer
References	[1]. Qin C, et al. Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression. J Med Chem. 2018 Aug 9;61(15):6685-6704.