2222768-84-3

2222768-84-3 structure

Name: Dynarrestin
Chemical Name: Dynarrestin
CAS Number: 2222768-84-3
Molecular Formula: C₂₂H₂₃F₂N₃O₂S
Molecular Weight: 431.50
Catalog: Signaling Pathways Stem Cell/Wnt Hedgehog
Create Date: 2019-10-06 14:16:25
Modify Date: 2024-01-10 23:53:05
Dynarrestin is a aminothiazole inhibitor of cytoplasmic dyneins 1 and 2. Dynarrestin rapidly and reversibly inhibits dynein 1-driven microtubule gliding in vitro plus a range of dynein 1- and 2-dependent processes in cells without affecting ATP hydrolysis and interfering with ciliogenesis. Dynarrestin suppresses hedgehog (Hh)-dependent proliferation of neuronal precursors and tumor cells[1].

Name	Dynarrestin
Synonyms	MFCD32174341

Description	Dynarrestin is a aminothiazole inhibitor of cytoplasmic dyneins 1 and 2. Dynarrestin rapidly and reversibly inhibits dynein 1-driven microtubule gliding in vitro plus a range of dynein 1- and 2-dependent processes in cells without affecting ATP hydrolysis and interfering with ciliogenesis. Dynarrestin suppresses hedgehog (Hh)-dependent proliferation of neuronal precursors and tumor cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Stem Cell/Wnt >> Hedgehog
References	[1]. Höing S, et al. Dynarrestin, a Novel Inhibitor of Cytoplasmic Dynein. Cell Chem Biol. 2018 Apr 19;25(4):357-369.e6.

Molecular Formula	C₂₂H₂₃F₂N₃O₂S
Molecular Weight	431.50