1627716-22-6

1627716-22-6 structure

Name: CD 161
Chemical Name: CD161
CAS Number: 1627716-22-6
Molecular Formula: C₂₆H₂₁N₅O₂
Molecular Weight: 435.48
Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
Create Date: 2019-10-07 19:49:52
Modify Date: 2025-08-25 17:01:29
CD161 is a potent and orally bioavailable bromodomain and extra-terminal (BET) bromodomain inhibitor with an IC50 of 28.2 nM and a Ki of 8.2 nM for BRD4 BD1[1]. CD161 is a C-type lectin-like receptor expressed on the majority of natural killer (NK) cells. CD161 demonstrates high selectivity over 24 non-BET proteins containing bromodomains[2].

Name	CD161

Description	CD161 is a potent and orally bioavailable bromodomain and extra-terminal (BET) bromodomain inhibitor with an IC50 of 28.2 nM and a Ki of 8.2 nM for BRD4 BD1[1]. CD161 is a C-type lectin-like receptor expressed on the majority of natural killer (NK) cells. CD161 demonstrates high selectivity over 24 non-BET proteins containing bromodomains[2].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Angiotensin Receptor Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain
Target	IC50: 28.2 nM (BRD4 BD1)[1]
In Vivo	CD161 has a good pharmacokinetic profile in mice and rats, and demonstrates strong antitumor activity in MV4;11 acute leukemia and MDA-MB-231 breast cancer xenograft models[1].
References	[1]. Yujun Zhao, et al. Structure-Based Discovery of CF53 as a Potent and Orally Bioavailable Bromodomain and Extra-Terminal (BET) Bromodomain Inhibitor.J Med Chem. 2018 Jul 26; 61(14): 6110–6120. [2]. Ayako Kurioka, et al. CD161 Defines a Functionally Distinct Subset of Pro-Inflammatory Natural Killer Cells. Front Immunol. 2018 Apr 9;9:486.

Molecular Formula	C₂₆H₂₁N₅O₂
Molecular Weight	435.48