CD 161
Modify Date: 2025-08-25 17:01:29
CD 161 structure
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Common Name | CD 161 | ||
|---|---|---|---|---|
| CAS Number | 1627716-22-6 | Molecular Weight | 435.48 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C26H21N5O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CD 161CD161 is a potent and orally bioavailable bromodomain and extra-terminal (BET) bromodomain inhibitor with an IC50 of 28.2 nM and a Ki of 8.2 nM for BRD4 BD1[1]. CD161 is a C-type lectin-like receptor expressed on the majority of natural killer (NK) cells. CD161 demonstrates high selectivity over 24 non-BET proteins containing bromodomains[2]. |
| Name | CD161 |
|---|
| Description | CD161 is a potent and orally bioavailable bromodomain and extra-terminal (BET) bromodomain inhibitor with an IC50 of 28.2 nM and a Ki of 8.2 nM for BRD4 BD1[1]. CD161 is a C-type lectin-like receptor expressed on the majority of natural killer (NK) cells. CD161 demonstrates high selectivity over 24 non-BET proteins containing bromodomains[2]. |
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| Related Catalog | |
| Target |
IC50: 28.2 nM (BRD4 BD1)[1] |
| In Vivo | CD161 has a good pharmacokinetic profile in mice and rats, and demonstrates strong antitumor activity in MV4;11 acute leukemia and MDA-MB-231 breast cancer xenograft models[1]. |
| References |
| Molecular Formula | C26H21N5O2 |
|---|---|
| Molecular Weight | 435.48 |
| InChIKey | AEANZCXROGPSBY-UHFFFAOYSA-N |
| SMILES | COc1cc2c(cc1-c1c(C)noc1C)[nH]c1nc(C)nc(-c3ccnc4ccccc34)c12 |