1303420-67-8

1303420-67-8 structure

Name: PLX5622
Chemical Name: PLX5622
CAS Number: 1303420-67-8
Molecular Formula: C₂₁H₁₉F₂N₅O
Molecular Weight: 395.41
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK c-Fms
Create Date: 2019-09-10 14:53:48
Modify Date: 2025-08-25 20:26:37
PLX5622 is a highly selective brain penetrant and oral active CSF1R inhibitor, for extended and specific microglial elimination, preceding and during pathology development. PLX5622 demonstrates desirable PK properties in varies animals[1].

Name	PLX5622

Description	PLX5622 is a highly selective brain penetrant and oral active CSF1R inhibitor, for extended and specific microglial elimination, preceding and during pathology development. PLX5622 demonstrates desirable PK properties in varies animals[1].
Related Catalog	Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Fms Research Areas >> Neurological Disease
Target	CSF1R[1].
References	[1]. Spangenberg E, et al. Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease model. Nat Commun. 2019 Aug 21;10(1):3758.

Molecular Formula	C₂₁H₁₉F₂N₅O
Molecular Weight	395.41